Tag: ll (page 3 of 44)

Why I Love Mercury Retrograde And Why You Could Too!

by Ines SuljMercury has just gone retrograde again. This time in Gemini, the sign it rules.All the planets, except Sun and Moon, go in apparent backward motion from time to time, yet the Mercury retrograde seems to be the most famous one. Almost everyone knows about it, including the people who know nothing about astrology and those who don’t even believe in it.In astrology, when a planet is in retrograde, it doesn’t actually move backwards in the sky. It only a [...]

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Why Do We Still Vaccinate? – 25 Questions From A Former Vaccine Advocate

Brian Rogers, Prevent DiseaseI used to be pro vaccine. I know the feeling of thinking others were just plain crazy and wrong for not vaccinating their children and themselves. ‘Irresponsible!’ I said when pointing my finger. I’d use the same old arguments about polio and small pox and how vaccines saved us from all those horrible diseases and just swallowing and regurgitating the propaganda I was brought up with. It was only recently, in 2009 that I started question [...]

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CRISPR-Cas9 modifies your DNA, under legal fire ~ Video




Excerpt from slashgear.com

A revolutionary method of editing the human genome has this week become the subject of a patent war. Back in April of 2014, patents were awarded by the USPTO (United States Patent and Trademark Office) to the Broad Institutes’ Dr. Feng Zhang, MIT, and Harvard to develop the technology behind "CRISPR-Cas9". 
This April, the UC Board of Regents’ legal team spoke with the USPTO about reconsidering their action, suggesting they award the patent to the inventor of the original method, UC Berkeley’s Jennifer Doudna. One way or another, this radical DNA modifier must be made. 

We need X-Men, after all.


The following video will explain what this genome-editing piece of technological breakthrough is all about. CRISPR-Cas9 is what it's called, and getting in to your body to make changes on a DNA level is what it's going for.

CRISPR-Cas9 works as a tiny scissors.

Utilizing the natural bacterial-level protective system used by your body to fight infections, CRISPR-Cas9 replicates the sequences of target DNA strands and latches on.

It's the connector that CRISPR-Cas9 makes real, and really programmable.

Your body provides the Cas9.* The Cas9 is the nuclease enzyme that cuts DNA strands.

*Correction - BACTERIA have Cas9, not our human selves. As helpful commenter "John" put so eloquently, "So far it has only been found in bacterial cells, and that's one of the things that makes it so amazing--a relatively simple molecular system that replicates many of the functions of our elaborate adaptive immune response, all in a single prokaryotic cell!"

Screen Shot 2015-05-15 at 10.11.42 AM
ABOVE: Image comes via Nature; Addgene, By Jonathan Corum, via NYT.

When a DNA sequence is cut, it may attempt to re-form. In doing so, it can create mutations.

But that's a discussion for another day.

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Genetically altered twin monkeys have been made using the CRISPR-Cas9 method. As you'll see in DOI: http://dx.doi.org/10.1016/j.cell.2014.01.027 in Cell Symposia "Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos", these monkeys are living large on gene-altered action.

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Today what's important is that two groups are fighting for the patents involved in CRISPR-Cas9.

A paper published online June 28 2012 by Science authored by Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A. Doudna, and Emmanuelle Charpentier describes the method: "A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity."

You can find this paper under code DOI: 10.1126/science.1225829.

Dr. Zhang suggests he demonstrated the CRISPR genome editing method before the 2012 paper was published by Dr. Doudna and Dr. Charpentier and crew. Dr. Doudna and Dr. Charpentier and crew suggest say Dr. Zhang's notebook (used as proof for patents) does not prove genome editing before the 2012 paper was published.

Can't we all just get along? Think of the monkeys!

Click to zoom

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Science: Plants Have Senses and Can Hear, Feel and Identify Attackers

Alisa Opar, GuestThe plant world is a violent place. When munching caterpillars or grazing cattle set their sights on a luscious leaf, a plant can’t hightail it out of harm’s way. Instead, flora fight back with noxious chemicals. But what repels one critter may not work on the next hungry mouth, explains Heidi Appel, a senior research scientist in the Bond Life Sciences Center at the University of Missouri. She’s found that some plants can actual [...]

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Here’s Why Tesla’s Battery Is A Big Deal


Excerpt from forbes.com

It’s more about where the market and product are going than where they are today. Think about a complementary system of components:

  1. The big grid – always on, highly reliable power which is expensive during peak demand hours, i.e. when a family actually wants to use the power. But usually the electricity is cheap at night when no one wants to use it and those big baseload plants that are hard (or very hard in the case of nuclear) to slow down are still pumping out power. And sometimes that power is provided by strong night winds.
  2. Home solar – Don’t forget that Tesla’s CEO, Musk, is also Chairman of SolarCity which provides zero down leasing. Home solar is often poorly aligned to peak usage, with installers looking for maximum generation with south-facing solar panels rather than maximum generation during peak with south-west facing panels. Then there are the homes with roofs that are poorly aligned to the sun regardless, so imperfect generation is all that is possible. And that peak generation isn’t necessarily perfectly aligned with peak cost of grid electricity either, but merely overlaps with it.
  3. Home storage – Maximum generation alignment of home solar matters less when you can carry forward the unconsumed electricity from solar panels to your evening of cooking, washing dishes, washing clothes, and streaming Netflix on your 40″ tv. And cheap electricity you can store at night and consume when electricity is really expensive is valuable as well.
So these components exist, but to be fair, they existed before Tesla got into the home storage business and have for a long time. And Tesla’s offering costs about twice as much as more typical lead-acid batteries commonly used for the purpose. So why is this particular home storage battery getting so much attention?
  1. Hype – Don’t underestimate the marvel that is Musk’s ability to get attention. The man is a rock star of event unveiling.
  2. Net metering – Right now, there is a lot of conflict between utilities and home solar users and installation companies. Net metering is the requirement that home solar generators get paid for electricity that they produce and pump into the grid, and only pay for the electricity that they draw from the grid. Output vs input is the net. Home solar used to be an advantage to utilities — reduced peak demand — but has become a liability — reduced or even negative revenue from users of the grid. Basically, utilities still have to pay for the grid which home solar generators use, then they lose revenue or outright pay the home solar generator who is getting use of the grid for free. Since utilities pay for the grid out of electricity revenue, they are starting to demand that people with home solar who aren’t paying much for electricity start paying for grid usage to make up for it. This is getting mixed reviews, as you can understand, but in the USA especially is leading to a desire by many to be completely grid free, a dubious value proposition. Tesla’s hype fell into an emerging market opportunity of people who had solar on their roof, didn’t have batteries but are worried that they’ll be forced to pay more.
  3. Time-of-use billing – Combined with smart meters, time-of-use billing is becoming much more common in utilities in the developed world. This model is simple: reduce demand during peak periods by increasing the price, typically combined with incenting shift of demand to off-peak times by lowering the price. Flattening demand curves, especially peaks, is very advantageous for grid managers because they have to have capacity for the peak. This enables storage to time-shift consumption and save at least some money.
  4. Design – Previous storage units are collections of lead acid batteries, basically the same thing you have in your car, but scaled vertically and horizontally. They aren’t pretty, they are heavy, they take up floor space, they require maintenance, and they are pretty much a toxic addition to homes if breached or even if the tops are removed. Tesla’s model is sleek, hangs on a wall and is much more chemically inert with no liquids. It’s a benign home appliance as opposed to an industrial object (much as some people like the industrial aesthetic at home, it’s less common).
  5. The Gigafactory – What Tesla has going for it is that it is building the world’s largest battery factory, and likely expanding it now that the storage line has taken off so brilliantly. Pretty much everyone paying attention knows that Tesla is already producing batteries much more cheaply on a per KWH capacity at greater volume, and the Gigafactory is going to ramp that up. Battery storage has been dropping in price per KWH of capacity for a long time, but it’s closing in on a cusp point where it’s going to be worth it for average consumers to store at least some electricity.
What all of this adds up to is that home battery storage isn’t economical today, but it’s viable for a subset of the high-consuming market, it’s desirable for its green credentials, it’s desirable due to the hype factor and it will defray its costs. And that the home storage market tomorrow will be viable for a much larger percentage of the market with increasing systemic pressures and pricing that will make it more attractive. Tesla’s home storage battery is getting attention because they are staking a major claim to a market which is expected to increase dramatically.
Why is Tesla’s battery a big deal?: originally appeared on Quora:

Answer by Mike Barnard, Energy guy, on Quora

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12 Signs Your Dog Is Basically Your Furry Child





thedodo.com

1. Snack time is no longer a solo activity ...


2. ... And you always have a little reminder of when it's dinner time.


3. You always have a bed buddy — whether there's room for one or not.


4. The word "messy" is now taken to a whole new level in your household.


5. You have more pictures of your pup than you do of people.


6. Your house is full of toys that do not belong to you.


7. You never need to set an alarm — you'll definitely be woken up in the mornings.


8. You no longer have sole ownership of your possessions ...


9. ... Or your food.


10. You take more pride in their accomplishments than you do your own.


11. You'd do anything to keep them from getting scared.


12. And the most telling sign? Your pup is always the most surefire way to brighten your day.



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22 Terrifying and Magical Capabilities Someone Has When You Fall For Them

Excerpt from huffingtonpost.comLove is terrifying, and terror is love.How exceptional is falling in love? How breathtakingly incredible? How painful and enchanted it is to have your heart opened. It presents so many chances for overwhelming pain, an...

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Your brain will never turn into software on a supercomputer

Excerpt from io9.com Getting ready to upload your consciousness into a brain-emulating computer in a decade or two? You'll be waiting a lot longer than that. Princeton computer science researcher Timothy B. Lee doesn't think we'll ever upload our ...

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