Tuesday, November 2, 2010 http://www.fightaging.org/archives/2010/11/salamanders-and-regeneration-research.php

Maria
Konovalenko looks at research into salamander biochemistry: "By tracking
individual cells in genetically modified salamanders, researchers have found an
unexpected explanation for their seemingly magical ability to regrow lost
limbs. Rather than having their cellular clocks fully reset and reverting to an
embryonic state, cells in the salamanders’ stumps became slightly less mature
versions of the cells they’d been before. The findings could inspire research
into human tissue regeneration. The cells don’t have to step as far back as we
thought they had to, in order to regenerate a complicated thing like a limb. There’s
a higher chance that human or mammalian cells can be induced into doing the
same thing. People working on are trying to de-differentiate cells
in an artificial fashion. It will be very important for the
regenerative-medicine community to take stock of what’s going o n in the
salamander, because they’ve been doing it for 360 million years, and found a
natural way to de-differentiate their tissues."